Sex and COVID-19: a protective role for reproductive steroids


Pinna G




Trends Endocrinol Metab . 2021 Jan;32(1):3-6.

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Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role.

Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, reshape competence of immune cells, stimulate antibody production, and promote proliferation and repair of respiratory epithelial cells, suggesting they may protect against COVID-19 symptoms.

Copyright © 2020 Elsevier Ltd. All rights reserved.

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