Medical Studies on Pregnenolone – Inflammation


Pregnenolone possesses powerful anti-inflammatory properties − a fact that has been known for decades − and supports the maintenance of immune homeostasis in various inflammatory conditions. It also plays a key role in many autoimmune concerns, for example, rheumatoid arthritis and multiple sclerosis (MS).

Proven for Inflammatory Joint Concerns

Since the 1940s, pregnenolone has been used successfully to promote healthy joints in instances of inflammatory joint concerns, including those with an autoimmune component, such as rheumatoid arthritis. Pregnenolone also helps relieve symptoms of osteoarthritis and can facilitate a delay in its progression. Pregnenolone is often better tolerated than other measures and standard treatments, as these are often accompanied by side effects such as high blood pressure or osteoporosis.

Anti-Inflammatory Mechanisms of Pregnenolone

According to studies, one aspect of the anti-inflammatory effect of pregnenolone appears to be related to glucocorticoids, specifically the immunosuppressive glucocorticoid receptor. However, pregnenolone is also capable of suppressing the inflammatory response via its own mechanism, independent of the receptor. In this respect, pregnenolone suppresses pro-inflammatory signals that can be mediated via microglial cells through the Toll-like receptor (TLR).

Medical Studies on Pregnenolone – Inflammation

BV-2 microglial cells respond to rotenone toxic insult by modifying pregnenolone, 5α-dihydroprogesterone and pregnanolone levels

2020-09 Avallone R, Lucchi C, Puja G, Codeluppi A, Filaferro M, Vitale G, Rustichelli C, Biagini G

Neuroinflammation, whose distinctive sign is the activation of microglia, is supposed to play a key role in the development and progression of neurodegenerative diseases. The aim of this investigation was to determine levels of neurosteroids produced by resting and injured BV-2 microglial cells.

The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation

2019-03 Murugan S, Jakka P, Namani S, Mujumdar V, Radhakrishnan G

Pregnenolone is a steroid hormone precursor that is synthesized in various steroidogenic tissues, in the brain, and in lymphocytes. In addition to serving as the precursor for other steroid hormones, pregnenolone exerts its own effect as an anti-inflammatory molecule to maintain immune homeostasis in various inflammatory conditions.

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan

2010-06 Ciurtin C, Majeed Y, Naylor J, Sukumar P, English AA, Emery P, Beech DJ

Calcium-permeable channels are known to have roles in many mammalian cell types but the expression and contribution of such ion channels in synovial cells is mostly unknown. The objective of this study was to investigate the potential relevance of Transient Receptor Potential Melastatin 3 (TRPM3) channel to fibroblast-like synoviocytes (FLSs) of patients with rheumatoid arthritis.

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