Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons


Majewska MD, Mienville JM, Vicini S




Neurosci Lett . 1988 Aug 1;90(3):279-84.

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Our earlier biochemical studies suggested that the neurosteroid pregnenolone sulfate (PS) may reduce gamma-aminobutyric acid (GABA) action at the Cl- channel associated with GABAA receptors.

In the present electrophysiological study the interaction of PS with the GABAA receptor was tested, using whole-cell voltage-clamp recordings from isolated cerebral cortical neurons of neonatal rats.

At micromolar concentrations PS reversibly inhibited GABA-induced current, behaving as an allosteric receptor antagonist.


Electrophysiological effects of pregnenolone on the GABA receptor. (Source: modified from Majewska MD et al. 1988)
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