Metabolism
Medical Studies on Pregnenolone – Metabolism
Pancreatic beta cells play a key role in diabetes mellitus. In this process, proinflammatory cytokines activate signaling pathways that can then lead to beta cell damage and death. Pregnenolone promotes healthy beta cell function in the pancreas and ensures the healthy physiological release of insulin, thanks to its anti-inflammatory properties.
Pregnenolone for Metabolic Disorders
Treatment with pregnenolone can be especially helpful for people over 40 who want to keep their blood glucose levels in the normal range; occasionally, it is also suitable for younger candidates with similar complaints. Studies have shown that pregnenolone supports the metabolic work of beta cells and can even renew these cells.
DHEA and Melatonin
Taking DHEA along with pregnenolone can enhance the effect of both substances, as pregnenolone is a direct precursor of DHEA. In studies, this has been shown to have a positive effect on insulin, sugar and fat metabolism and to exert a protective effect against insulin resistance. Pregnenolone can also be effectively used in conjunction with melatonin. Together they enhance each other’s ability to promote healthy insulin secretion and also provide energy balance while promoting stress control and recovery.
Medical Studies on Pregnenolone – Metabolism
Relationship of dehydroepiandrosterone sulfate levels with atherosclerosis in patients with subclinical hypothyroidism
Subclinical hypothyroidism is related with increased risk of cardiovascular diseases. The decreased levels of dehydroepiandrosterone sulphate (DHEA-S) are associated with hyperlipidemia, atherosclerosis and obesity. The lower levels of DHEA‑S might be an important factor in development of atherosclerosis in subclinical hypothyroidism.
Role of endocannabinoids in energy-balance regulation in participants in the postobese state – a PREVIEW Study
Endocannabinoids are suggested to play a role in energy balance regulation. We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes.
Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period
Dehydroepiandrosterone (DHEA), mostly present as its sulfated ester (DHEA-S), is an anabolic hormone that naturally declines with age. Furthermore, it is the most abundant androgen and estrogen precursor in humans.
Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women
Obesity-related alterations in the circulating steroid hormone profile remain equivocal in women. Our objective was to identify circulating steroid levels that relate to increased adiposity and altered adipose phenotype in premenopausal women.
Adrenocorticotropin acutely regulates pregnenolone sulfate production by the human adrenal in vivo and in vitro
Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulation, and adrenocorticotropic hormone (ACTH) is considered the major regulator of its synthesis. Pregnenolone sulfate (PregS) and 5-androstenediol-3-sulfate (AdiolS) have recently emerged as biomarkers of adrenal disorders.
Steroid hormone profiling in obese and nonobese women with polycystic ovary syndrome
The study explored differences in the steroidogenic pathway between obese and nonobese women with polycystic ovary syndrome (PCOS) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Role of sex steroids in β-cell function, growth, and survival
The gonads have long been considered endocrine glands, producing sex steroids such as estrogens, androgens, and progesterone (P4) for the sole purpose of sexual differentiation, puberty, and reproduction.
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells
Transient receptor potential (TRP) cation channels are renowned for their ability to sense diverse chemical stimuli.
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways
Traditional pharmacologic approaches had identified several classes of xenobiotics that elicited characteristic biological effects in vivo but that lacked defined molecular mechanisms of action.