Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics2006-06 Marx CE, Stevens RD, Shampine LJ, Uzunova V, Trost WT, Butterfield MI, Massing MW, Hamer RM, Morrow AL, Lieberman JAEvidence suggests that neuroactive steroids may be candidate modulators of schizophrenia pathophysiology and therapeutics.