pharmaco-fMRI

Medical Studies on Pregnenolone

The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity

2014-07 Sripada RK, Welsh RC, Marx CE, Liberzon I

The neurosteroids allopregnanolone and dehydroepiandrosterone (DHEA) are integral components of the stress response and exert positive modulatory effects on emotion in both human and animal studies.

Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits

2013-06 Sripada RK, Marx CE, King AP, Rampton JC, Ho S, Liberzon I

The neurosteroid allopregnanolone is a potent allosteric modulator of the gamma-aminobutyric acid type A receptor with anxiolytic properties. Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective functioning.

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