The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis
The fundamental framework of steroidogenesis is similar across steroidogenic cells, especially in initial mitochondrial steps.
mitochondria
Medical Studies on Pregnenolone
Steroids and Alzheimer’s disease: changes associated with pathology and therapeutic potential
Alzheimer's disease (AD) is a multifactorial age-related neurodegenerative disease that today has no effective treatment to prevent or slow its progression. Neuroactive steroids, including neurosteroids and sex steroids, have attracted attention as potential suitable candidates to alleviate AD pathology.
TSPO ligands boost mitochondrial function and pregnenolone synthesis
Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and plays an important role in steroidogenesis and cell survival. In the central nervous system (CNS), its expression is upregulated in neuropathologies such as Alzheimer's disease (AD).