A role of endogenous progesterone in stroke cerebroprotection revealed by the neural-specific deletion of its intracellular receptors
Treatment with progesterone protects the male and female brain against damage after middle cerebral artery occlusion (MCAO). However, in both sexes, the brain contains significant amounts of endogenous progesterone. It is not known whether endogenously produced progesterone enhances the resistance of the brain to ischemic insult.