The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis
The fundamental framework of steroidogenesis is similar across steroidogenic cells, especially in initial mitochondrial steps.
cholesterol
Medical Studies on Pregnenolone
Sex dimorphism in an animal model of multiple sclerosis: focus on pregnenolone synthesis
Neuroactive steroids, molecules produced from cholesterol in steroidogenic cells (i.e., peripheral glands and nervous system) are physiological modulators and protective agents of nervous function. A possible role for neuroactive steroids in the sex-dimorphic clinical manifestation, onset and progression of Multiple Sclerosis (MS) has been recently suggested.
The role of miRNAs in regulating adrenal and gonadal steroidogenesis
miRNAs are endogenous noncoding single-stranded small RNAs of ~22 nucleotides in length that post-transcriptionally repress the expression of their various target genes. They contribute to the regulation of a variety of physiologic processes including embryonic development, differentiation and proliferation, apoptosis, metabolism, hemostasis and inflammation.